Part 1: Understanding Small Intestinal Bacterial Overgrowth (SIBO)
- Colleen DeSimone
- Jan 22
- 2 min read
Updated: Jan 23

Small Intestinal Bacterial Overgrowth (SIBO) is a chronic condition in which bacteria, typically found in the large intestine, overgrow in the small intestine. Normally, the small intestine houses fewer bacteria—less than 10,000 bacteria per milliliter—compared to the large intestine, which is home to billions of bacteria. These intestinal bacteria play an essential role in the digestive process, helping absorb nutrients, protecting against harmful pathogens, and producing vital nutrients like folate and vitamin K.
In a healthy system, the small intestine remains relatively clear of excess bacteria due to several protective mechanisms. Gastric acid helps maintain an acidic environment, which limits bacterial growth, while the migrating motor complex (MMC) is responsible for cleaning out the intestines by moving waste along.
Additionally, immunoglobulins in the intestinal fluid offer protection, and the ileocecal valve—located between the small intestine and large intestine—prevents back flow of bacteria from the colon into the small intestine.
However, when any of these protective mechanisms become impaired, bacteria from the large intestine can migrate into the small intestine, causing SIBO. This overgrowth disrupts the balance of gut bacteria and leads to a variety of digestive and systemic issues.
Common Symptoms of SIBO
SIBO manifests in a wide range of symptoms, making it sometimes challenging to diagnose. Some common symptoms include:
Abdominal discomfort and bloating
Fatigue and brain fog
Diarrhea or constipation
Skin issues like acne or eczema
Unexplained weight changes
Food sensitivities
Mental health symptoms, including anxiety and depression
Flatulence and belching
The complexity of SIBO’s symptoms often overlaps with other conditions, which can lead to delayed diagnosis and treatment.
Causes of SIBO
The root cause of SIBO is usually multifactorial. Several factors may contribute to the development of SIBO, including:
Ileocecal valve dysfunction: If this valve doesn’t close properly, it can allow bacteria to migrate from the large intestine back into the small intestine.
Altered gut motility: When the MMC is impaired, bacteria in the small intestine cannot be cleared effectively, creating an environment conducive to bacterial overgrowth.
Gastric acid suppression: Medications that reduce stomach acid or conditions that impair acid production can allow bacteria to thrive in the small intestine.
Immunocompromised states: If the immune system is weakened, it may not be able to control the bacterial population in the gut, leading to overgrowth.
Chronic use of antibiotics or medications: Antibiotics can disrupt the balance of bacteria in the gut, increasing the likelihood of SIBO development.
Stay Tuned for Part II & Stay Vibrant and Well-Nourished, Friends!
Disclaimer: Please note that the information provided in this post is for educational purposes only and should not be construed as medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Additionally, while nutrients play a vital role in supporting overall health, not all nutrients are suitable for all individuals. Before making any changes to your diet or supplementation regimen, it's essential to consult with a qualified healthcare professional, especially if you have any underlying health conditions or are taking medications. Always prioritize your health and well-being by seeking personalized guidance from a healthcare provider.