Gut Brain Axis
- Colleen DeSimone
- Jan 14
- 3 min read
Updated: Jan 23

Let's delve into the intricate relationship between gut health, cognitive function, and the nutrients that support both. Our gut and brain communicate bidirectionally through the gut-brain axis, influencing various aspects of health and well-being.
Gut Health and Neural Compensation: Did you know that gut health plays a crucial role in neural compensation? A healthy gut microbiome supports optimal neurotransmitter production and regulates inflammation, providing a stable foundation for neural function.
Nutrients like omega-3 fatty acids, B vitamins, and antioxidants promote gut health and neural resilience, helping the brain adapt to challenges and maintain cognitive performance.
Nutrients that support overall brain health and function include:
Omega-3 fatty acids (EPA and DHA)
B vitamins (especially B6, B9, and B12)
Vitamin D
Magnesium
Antioxidants (e.g., vitamins C and E, selenium)
Phosphatidylserine
Acetyl-L-carnitine
Gut Health and Neuroplasticity: The gut microbiome also influences neuroplasticity, the brain's ability to adapt and reorganize. By producing neurotransmitters and modulating synaptic activity, gut microbes shape neural networks and promote cognitive flexibility. Nutrients such as phospholipids, polyphenols, and N-acetyl cysteine support neuroplasticity by enhancing synaptic communication and protecting neurons from oxidative stress.
Nutrients that promote synaptic plasticity and neuronal communication include:
Omega-3 fatty acids (especially DHA)
Choline
Phospholipids (e.g., phosphatidylcholine, phosphatidylserine)
Brain-derived neurotrophic factor (BDNF) enhancers (e.g., curcumin, resveratrol)
N-acetyl cysteine (NAC)
Polyphenols (e.g., flavonoids, anthocyanins)
Gut Health and Functional Reorganization: Changes in gut microbiota composition can impact functional reorganization within the brain. Dysbiosis, or microbial imbalance, may alter neurotransmitter signaling and impair cognitive function. Nutrients like choline, lion's mane mushroom extract, and Bacopa monnieri promote a healthy gut-brain axis, supporting neural connectivity and cognitive resilience.
Nutrients that support cognitive function and neural connectivity include:
Choline
Phospholipids (e.g., phosphatidylcholine, phosphatidylserine)
Acetyl-L-carnitine
Lion's mane mushroom extract
Bacopa monnieri
Ginkgo biloba
Alpha-GPC (glycerophosphocholine)
Gut Health and Neurochemical Changes: The gut microbiome produces neurotransmitters and regulates their availability, influencing cognitive processing speed and mood. Disruptions in gut health can lead to neurochemical imbalances associated with cognitive decline and mood disorders. Nutrients such as precursors to neurotransmitters, monoamine oxidase inhibitors (MAOIs), and GABAergic compounds support neurotransmitter synthesis and balance, promoting cognitive vitality.
Nutrients that modulate neurotransmitter synthesis, release, and receptor function include:
Precursors to neurotransmitters (e.g., tyrosine for dopamine, tryptophan for serotonin)
Cofactors for neurotransmitter synthesis (e.g., vitamin B6, magnesium)
Monoamine oxidase inhibitors (MAOIs) (e.g., curcumin, green tea catechins)
Serotonin precursors (e.g., 5-HTP)
GABAergic nutrients (e.g., L-theanine, taurine)
Dopaminergic nutrients (e.g., L-tyrosine, phenylalanine)
Gut Health and Task-Specific Factors: Lastly, gut health impacts task-specific cognitive performance through its influence on neurotransmitter availability and systemic inflammation. A healthy gut microbiome supports optimal brain function during tasks requiring attention, memory, and executive function. Nutrients like caffeine, adaptogenic herbs, and mitochondrial enhancers enhance cognitive performance by promoting alertness, stress resilience, and energy production.
Nutrients that support specific cognitive functions or processes involved in the task include:
Caffeine (for alertness and attention)
Adaptogenic herbs (e.g., Rhodiola rosea, Ashwagandha) (for stress resilience and cognitive function)
Nootropic compounds (e.g., racetams, modafinil) (for cognitive enhancement and focus)
Mitochondrial enhancers (e.g., coenzyme Q10, acetyl-L-carnitine) (for energy production and cognitive performance)
By nourishing our gut with nutrient-rich foods and supporting cognitive function with targeted supplementation, we can optimize the gut-brain axis and unlock our full potential. Remember, a healthy gut is the foundation for a thriving mind and body!
Stay vibrant and well-nourished, friends!
Disclaimer: Please note that the information provided in this post is for educational purposes only and should not be construed as medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Additionally, while nutrients play a vital role in supporting overall health, not all nutrients are suitable for all individuals. Before making any changes to your diet or supplementation regimen, it's essential to consult with a qualified healthcare professional, especially if you have any underlying health conditions or are taking medications. Always prioritize your health and well-being by seeking personalized guidance from a healthcare provider.